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Swift 2S Turbo DNA Library Prep Kits

Library normalisation technology for NGS
NGS library prep from limited samples

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Oncology & liquid biopsy

To better understand complex diseases such as cancer, researchers study a variety of patient-derived samples. These include formalin-fixed paraffin-embedded (FFPE) tissue biopsy material, and liquid biopsy samples such as blood, cerebrospinal fluid, and urine. Oncology-related sample types can present a significant challenge for next generation sequencing (NGS) approaches, however it is widely acknowledged that NGS has a growing role in cancer detection, diagnosis, and monitoring. Using innovative technologies designed to overcome common issues such as DNA damage or low input, it is now possible to generate NGS libraries from even the most problematic sample types.

Cambridge Bioscience offers a range of products to support library generation and targeted sequencing of oncology-related samples. Developed to expand NGS capabilities and accelerate workflows, these deliver the high-quality data you require from precious, often limiting sample material.

Accel-NGS 2S DNA Library Kits
Using proprietary technology to generate libraries with low duplication rates and high complexity, even from highly damaged FFPE or low input circulating cell-free DNA (cfDNA) samples, Swift Biosciences’ Accel-NGS 2S DNA Library Kits allow processing of double-stranded DNA inputs as low as 10 pg. Including kits to support a range of whole genome sequencing (WGS) applications, and products designed to minimise duplicates or provide PCR-free NGS preparation, the Accel-NGS 2S product family benefits from specific protocol recommendations for various oncology-related sample types.

Swift Hybridization Capture Kits
Designed to reduce sequencing costs by targeting only genes of interest, Swift Hybridization Capture Kits enable detection of low occurrence variants down to 1% allele frequency. Included within the Swift Hybridization Capture Kits product family, the pan-cancer panel consists of 7816 Swift Probes, spanning 800 kb of the human genome, for the enrichment of 127 significantly mutated genes implicated across 12 tumour tissue types. Used in combination with optimised hybridization reagents and protocols this delivers comprehensive coverage of human coding sequences relevant to oncology research.

Accel-Amplicon NGS Panels
Swift Biosciences’ Accel-Amplicon NGS Panels employ a rapid, 2-hour workflow to prepare ready-to-sequence libraries. Including pre-designed panels for cancer gene profiling, the product range uses primer pairs which are compatible with short DNA fragments and designed for generating libraries from input DNA as low as 10 ng. This facilitates applications which utilise limiting or damaged samples such as FFPE and cfDNA and provides a powerful solution for detecting variants and screening clinically relevant mutations with a limit of detection down to 1%.

Swift Amplicon High Sensitivity (HS) panels
Optimised for performance with short FFPE and cfDNA fragments, Swift Amplicon High Sensitivity Panels enable ultra-low frequency variant detection to facilitate earlier discovery of tumour growth and identification of important driver mutations. Sensitive and highly specific detection of single nucleotide variants (SNVs) and indels down to 0.25% allele frequency is achieved by using molecular identifiers (MIDs) to uniquely label target templates during amplification. This is delivered within a workflow of just 3 hours from DNA to Illumina® compatible libraries.

Featured products within Oncology & liquid biopsy

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Swift Biosciences