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Comprehensive Epigenetic Profiling and Screening Services
Automated Cell Imaging System - JuLIStage

Molecular Biology Services

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hERG Channel Trafficking

Cambridge Bioscience offers access to a hERG channel trafficking screening service from B’SYS. Determining the current density and fraction of partly and fully glycosylated channel proteins, this electrophysiological screening service enables the assessment of hERG risk even in molecules which alter the surface concentration of the channel (by inhibiting processing in the endoplasmic reticulum or reducing trafficking of the protein to the cell surface) which would not be seen in acute ion channel assays.

Benefits Of Using This hERG Channel Trafficking Screening Service
• Detects large & small drug molecules that produce hERG risk by inhibiting protein trafficking from the endoplasmic reticulum
• Identifies large & small drug molecules that block hERG directly
• Fully validated against known hERG trafficking inhibitors
• Large & small drug molecules are run at 3 concentrations in triplicate

Material Available For Download
Luminescence Based Assay Datasheet

Contact Our Specialists
To discuss an hERG channel trafficking project, please contact our Instruments and Services specialists by Clicking Here

Contact Our B'SYS Specialist, Vashu