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GLP Compliant Safety Pharmacology Services


Automated Cell Imaging System - JuLIStage

Upgrading Your Laser Scanner? Consider The Sapphire™

hERG Channel Trafficking Screening

Cambridge Bioscience offers access to a hERG channel trafficking screening service from B’SYS. Determining the current density and fraction of partly and fully glycosylated channel proteins, this electrophysiological screening service enables the assessment of hERG risk even in molecules which alter the surface concentration of the channel (by inhibiting processing in the endoplasmic reticulum or reducing trafficking of the protein to the cell surface) which would not be seen in acute ion channel assays.

Benefits Of Using This hERG Channel Trafficking Screening Service
• Detect large & small drug molecules producing hERG risk by inhibiting protein trafficking from the endoplasmic reticulum
• Identify large & small drug molecules that block hERG directly
• Fully validated against known hERG trafficking inhibitors
• Large & small drug molecules run at 3 concentrations in triplicate

Material Available For Download
Luminescence Based Assay Datasheet

Contact Our Specialists
To discuss an hERG channel trafficking project, please contact our B'SYS specialist by Clicking Here

Contact Our B'SYS Specialist, Vashu