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Product types:
Optimised 3D Cell Culture Scaffold
GLP Compliant Safety Pharmacology Services
Ion Channel Screening & Profiling Services

Upgrading Your Laser Scanner? Consider The Sapphire™

Comprehensive In Vitro Proarrhythmia Assay (CIPA)

Cambridge Bioscience, through B’SYS, offers access to a fully defined, comprehensive in vitro proarrhythmia assay (CIPA) package addressing the CIPA Initiative which will replace existing ICH S7a/b guidelines.

Combining cardiac ion channel panel screening (using pharmacological profiling through classical patch clamp electrophysiology) and the screening of validated beating iPSC human cardiomyocytes (on the multiple-electrode array (MEA) against reference compounds with known clinical outcomes), this service provides a more comprehensive screening than measuring hERG-induced QT prolongation alone. 

Benefits Of Using This CIPA Package
• High quality data
• Comprehensive cardiac safety screen
• Multiple ion channel effects screen included - testing for hERG, Cav1.2 & Nav1.5
• Low to high throughput formats available
• Superior to hERG model in predicting Torsade de Pointes
• Fast 2-4 week timeline

Contact Our Specialists
To discuss a CIPA package project, please contact our B'SYS specialist by Clicking Here

Contact Our B'SYS Specialist, Vashu