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Comprehensive In Vitro Proarrhythmia Assay


GLP Compliant Safety Pharmacology Services

Transfection Ready Plasmid DNA In 20 Minutes With ZymoPURE II

Comprehensive In Vitro Proarrhythmia Assay (CIPA)

Cambridge Bioscience, through B’SYS, offers access to a fully defined, comprehensive in vitro proarrhythmia assay (CIPA) package addressing the CIPA Initiative which will replace existing ICH S7a/b guidelines.

Combining cardiac ion channel panel screening (using pharmacological profiling through classical patch clamp electrophysiology) and the screening of validated beating iPSC human cardiomyocytes (on the multiple-electrode array (MEA) against reference compounds with known clinical outcomes), this service provides a more comprehensive screening than measuring hERG-induced QT prolongation alone. 


Benefits Of Using This CIPA Package
• High quality data
• Comprehensive cardiac safety screen
• Multiple ion channel effects screen included - testing for hERG, Cav1.2 & Nav1.5
• Low to high throughput formats available
• Superior to hERG model in predicting Torsade de Pointes
• Fast 2-4 week timeline

CIPA Package Using Stem Cell-Derived Human Cardiomyocytes (SC-hCMs)

CIPA voltage

Example of CIPA voltage protocol for hERG (IKr)

MEA analysis

Example of MEA analysis using the Nanion CardioExcyte96™, combining impedance (IMP, cell contractility) and electrical field potential (EFP) measurements to investigate short- and long-term pharmacological effects on cardiomyocytes, including beat rate, beating accuracy, amplitude, rise/fall time and pulse width of the IMP signal as well as the amplitude and field potential duration of the EFP signal. The assay provides information on drug-induced alteration or impairment of contractility and EFP of SC-hCMs.

Contact Our Specialists
To discuss a CIPA package project, please contact our B'SYS specialist by Clicking Here

Contact Our B'SYS Specialist, Vashu