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Custom PiggyBac Transposon Vector Construction
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CNS Panel Screening

Cambridge Bioscience offers several ion channel screening panels for the central nervous system (CNS) from B’SYS. Designed to assess the neurotoxic, addictive or sedative potential of a compound on the CNS, this screening service includes a general CNS Explorer panel, to memory, pain and anti-epilepsy panels enabling drug development programs to establish undesirable side effects sooner.

Early CNS Explorer Panel (Automated Screen)

Ion Channel Gene
Kv7.2/7.3 (m current) KCNQ2/3
Kv1.1 KCNA1
Kv1.2 KCNA2
Kv1.3 KCNA3
Kv1.4 KCNA4
Kv1.6 KCNA6
Kv2.1 KCNB1
Kv2.2 KCNB2
Neuroblastoma whole cell potassium currents Various
Nav1.1 SCN1A
Nav1.2 SCN2A
Nav1.3 SCN3A
Nav1.6 SCN8A
Nav1.7 SCN9A
Nav1.8 SCN10A
Neuroblastoma whole sodium currents Expression: SCN9A>SCN8A>SCN2A>SCN3A>SCN10A>SCN11A
Cav2.1 CACNA1A / CACNB3 /CACNA2D2 or CACNA2D4
Cav3.1 CACNA1G
Cav3.2 CACNA1H
GABAA (α1β2γ2) GABRA1 / GABRB2 / GABRG2
GABAA (α1β3γ2) GABRA1 / GABRB3 / GABRG2
GABAA (α2β2γ2) GABRA2 / GABRB2 / GABRG2
GABAA (α3β2γ2) GABRA3 / GABRB2 / GABRG2
GABAA (α4β3d) GABRA4 / GABRB3 / GABRD
GABAA (α5β2γ2) GABRA5 / GABRB2 / GABRG2
GABAA (α6β3d) GABRA6 / GABRB3 / GABRD
Glycine (GlyRα3) GLYRA3
nAChR (α4β2) CHRNA4 / CHRNB2
nAChR (α7) CHRNA7
Serotonin 5HT3A HTR3A
P2X2 P2RX2
P2X4 P2RX4
P2X7 P2RX7
AMPA GRIA1
Kainate K2 GRIK2
NMDA (NR1/2A) GRIN1 / GRIN2A
NMDA (NR1/2B) GRIN1 / GRIN2B
NMDA (NR1/2D) GRIN1 / GRIN2D
HCN1 HCN1
TRPV1 TRV1(VR1)
TRPV2 TRV2
ASIC1a ACCN2 (long/short)
ASIC1b ACCN2 (long/short)
ASIC2 ACCN1
ASIC3 ACCN3

Memory Panel

Ion Channel Gene
GABAA (α5ß2γ2) GABRA5 / GABRB2 / GABRG2
AMPA AMPA1
NMDA NR1 / 2A
NMDA NR1 / 2B
nAchR (α4ß2) CHRNA4 / CHRNB2
nAchR (α7) CHRNA7

Pain panel

Ion Channel Gene
GABAA (α1ß2γ2) Fluorescence HTS GABRA1 / GABRB2 / GABRG2
GABAA (α1ß2γ2) GABRA1 / GABRB2 / GABRG2
GABAA (α1ß3γ2) GABRA1 / GABRB3 / GABRG2
GABAA (α2ß2γ2) GABRA2 / GABRB2 / GABRG2
GABAA (α3ß2γ2) GABRA3 / GABRB2 / GABRG2
GABAA (α5ß2γ2) GABRA5 / GABRB2 / GABRG2
Glycine (GlyRα3) GLYRA3
AMPA GRIA1
NMDA (NR1/2A) GRIN1 / GRIN2A
NMDA (NR1/2B) GRIN1 / GRIN2B
TRPV1 TRPV1 (VR1)
TRPV2 TRPV1
Nav1.8 SCN10A

Anti-epileptic Panel

Ion Channel Gene
Kv7.2 KCNQ2
Nav1.1 SCN1A
Nav1.2 SCN2A
Nav1.3 SCN3A
Nav1.6 SCN8A
Nav1.7 SCN9A
Nav1.8 SCN10A
Neuroblastoma whole sodium (TTX sensitive sodium channels)  
Cav2.1 CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4
CIC-2 CLCN2 20
GABAA (α1ß2γ2) GABRA1 / GABRB2 / GABRG2
GABAA (α1ß3γ2) GABRA1 / GABRB3 / GABRG2
GABAA (α2ß2γ2) GABRA2 / GABRB2 / GABRG2
GABAA (α3ß2γ2) GABRA3 / GABRB2 / GABRG2
GABAA (α5ß2γ2) GABRA5 / GABRB2 / GABRG2
GABAA (α1ß2γ2) Fluorescence GABRA1 / GABRB2 / GABRG2
Glycine (GlyRα3) GLRA3
AMPA AMPA1
NMDA NR1 / 2A
NMDA NR1 / 2B

 

Contact Our Specialists
To discuss a CNS channel screening project, please contact our B'SYS specialist by Clicking Here

Contact Our B'SYS Specialist, Vashu