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Safe sample collection, handling and transport

Bottlenecks in the availability of sample collection devices and transport media have caused major problems for some COVID testing centres. Shortages of biosafety cabinets in some labs mean that the safe handling of infectious samples has been challenging, limiting the number of tests that can be carried out. The DNA/RNA Shield Swab Collection Device and DNA/RNA Shield Saliva/Sputum Collection Device (sputum collection only) from Zymo Research are CE-IVD marked devices which have also been EUA granted to Zymo Research as part of their COVID testing workflow. These devices contain the DNA/RNA shield preservation and pathogen inactivation reagent.

Benefits of using DNA/RNA Shield
• CE marked collection devices/bulk reagents
• Preserves RNA integrity
• Deactivates pathogens (viruses, bacteria, fungi and parasites)
• Safe, room temperature, shipping and handling
• Compatible with most RNA extraction kits, without reagent removal

Worldwide use
These devices and reagents are in use in numerous NHS and private testing labs in the UK as well as globally in public and private molecular diagnostics labs. More information can be found here

Sample collection devices and purchasing options
We can provide large numbers of CE marked sample collection devices, including saliva collection devices (R1210-E) and collection tubes with swab (R1107-E), filled with the DNA/RNA shield sample preservation/pathogen inactivating reagent, to meet your requirements. Alternatively, bulk quantities of the DNA/RNA shield reagent are available, to use with your own collection devices, or individually wrapped swabs, to use with your own medium. We have several other options for sample collection. Further information can be found here
To find out more about our sample collection devices, contact our technical specialists.

DNA/RNA Shield sample collection devices

Pathogen inactivation
DNA/RNA Shield has been rigorously tested for its ability to deactivate a wide range of pathogens, including MERS coronavirus, Ebola and M. tuberculosis, without the need for additional steps, such as heat-treatment, homogenisation or alcohol sterilisation. In an independent study, the virucidal activity was shown to inactivate murine parvovirus1. DNA/RNA Shield abides by the Center for Disease Control’s (CDC) guidelines for pathogen inactivation2.

Pathogen type Species inactivated
Viruses MERS-coronavirus, Parvovirus, Chikungunya virus, Dengue virus, Ebola virus, Herpes simplex virus-1, Herpes simplex virus-2, Influenza A, Rhinovirus, West Nile virus
Bacteria B. subtilis, E. faecalis, E. coli, L. fermentum, L. monocytogenes, M. tuberculosis, P. aeruginosa, S. enterica, S. aureus, S. pneumoniae, X. fastidiosa
Yeast and eukaryotes C. albicans , C. neoformans , S. cerevisiae , P. malariae


1. Dr. Thraenhart and Dr. Jursch. Virucidal activity of the nucleic acid preservation product “DNA/RNA Shield™” against the murine parvovirus (MVM) at 20 °C. 
2. Guidance on the inactivation or removal of select agents and toxins for future use. Center for Disease Control (CDC)

Material available for download
DNA/RNA Shield: For safe, effective COVID-19 surveillance
DNA/RNA Shield swab collection kit protocol
DNA/RNA Shield protocol
Eurovir® DNA/RNA Shield test report
DNA/RNA Shield inactivation citations
DNA/RNA Shield COVID-19 inactivation declaration

Free samples
Request a free DNA/RNA Shield sample

Zymo Research has filed for Emergency Use Authorisation (EUA) w/ the FDA for its collection, extraction, and RT-PCR workflow for COVID-19 Testing.


Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
DNA/RNA Shield R1100-50 · Zymo Research
Zymo Research
50 ml £82.00
50 ml
DNA/RNA Shield R1100-250 · Zymo Research
Zymo Research
250 ml £281.00
250 ml
DNA/RNA Shield Collection Tube withSwab – Dx (1 ml fill) (CE-IVD) R1107-E · Zymo Research
Zymo Research
50 pack £415.00
50 pack
DNA/RNA Shield Saliva Collection Kit – Dx (1 x 2 ml fill) (CE-IVD) R1210-E · Zymo Research
Zymo Research
1 kit POA
1 kit