In-situ proximity ligation: NaveniSpec

The NaveniSpec kits, utilise the Naveni Proximity Ligation Technology to provide an integrated system for investigation of difficult to detect phosphorylated receptor tyrosine kinases. The unique technology utilises specific antibodies that conjugate to the detection system, minimising the need for time- and resource-intensive assay optimisation. 

The NaveniSpec range includes common Receptor Tyrosine Kinases (RTKs) that are integral to cancer signalling, developmental biology, and drug efficacy studies.

Find out more about Naveni proximity ligation technology

Benefits of using the NaveniSpec kit
• Ideal for detection of low-abundant phosphorylated proteins
• Compatiable with culture cells, fresh-frozen and FFPE samples
• Easy, one-day protocol with all neccessary reagants included
• Stronger signal and higher signal-to-noise ratio for easier quantification compared to immunofluorescence

The NaveniSpec kits demonstrate enhanced specificity over conventional immunofluorescence techniques

Comparison of pTyr cMet detection in unstimulated and stimulated A431 cells using NaveniSpec pTyr cMet against conventional Immunofluorescence pMet antibody. Demonstrates the enhanced specificity of the NaveniSpec pTyr cMet kit over conventional immunofluorescence techniques. 

The NaveniSpec kits reveal the protein activity states in the target tissue

Material available for download
NaveniSpec PTM flyer