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2D cell culture ECM surface coatings: NativeCoat

NativeCoat™ from Xylyx is a solubilised, tissue-specific extracellular matrix with native biochemical (porcine) cell composition to maintain phenotype in 2D cell culture. Demonstrating consistent lot-to-lot composition, NativeCoat contains the full milieu of proteins and growth factors to recapitulate the native cell environment in vitro to enable increased cell attachment, viability and proliferation as well as enhanced function and activation of signalling pathways.

Benefits of using NativeCoat
• Contains tissue-specific ECM components
• Lot-to-lot consistency
• Easy-to-use

Sinusoidal endothelial cell viability

Primary human liver sinusoidal endothelial cells cultured in microfluidic channels exhibited uncontrolled outgrowth and loss of viability after 7 days with no coating. In contrast, coating channels with NativeCoat™ Liver ECM supported controlled growth and viability of primary liver sinusoidal endothelial cells for 7 days

Primary human liver sinusoidal endothelial cells cultured in microfluidic channels exhibited uncontrolled outgrowth and loss of viability after 7 days with no coating. In contrast, coating channels with NativeCoat Liver ECM supported controlled growth and viability of primary liver sinusoidal endothelial cells for 7 days.

Applications
• Cell culture
• Cancer research
• Stem cell research
• Tissue engineering
• Clinical applications
• Drug screening
• Organ-on-a-chip

NativeCoat citations

Material available for download
NativeCoat 2D ECM surface coatings manual
NativeCoat datasheet

Custom projects
Standard NativeCoat ECM products are derived from porcine tissues. However, the Xylyx platform technology allows matrix isolation from different tissue sources, including human tissues according to specific requests. Discuss a custom project with our Xylyx specialist.

Products

Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
IN SITE™ Metastasis Surface Coating Kit MTSMS201 · Xylyx
MTSMS201
Xylyx
1 ml per each of 3 tissue types £186.00
1 ml per each of 3 tissue types
view
NativeCoat™ Bone ECM Surface Coating MTSBN201 · Xylyx
MTSBN201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Cartilage ECM Surface Coating MTSCT201 · Xylyx
MTSCT201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Heart ECM Surface Coating MTSHT201 · Xylyx
MTSHT201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Intestine ECM Surface Coating MTSIN201 · Xylyx
MTSIN201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Kidney ECM Surface Coating MTSKY201 · Xylyx
MTSKY201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Liver ECM Surface Coating MTSLV201 · Xylyx
MTSLV201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Lung ECM Surface Coating MTSLG201 · Xylyx
MTSLG201
Xylyx
1 ml £74.00
1 ml
view
NativeCoat™ Skin ECM Surface Coating MTSSK201 · Xylyx
MTSSK201
Xylyx
1 ml £74.00
1 ml
view