The in situ Proximity Ligation assay kits from Navinci detect the interaction of PD1/PD-L1 and phosphorylated PD1, utilising the proprietary Naveni Proximity Ligation Technology. Ideal for identifying the interaction of low abundant PD1/PD-L1, these assay kits give a high signal-to-noise ratio and use dual antibody recognition for more sensitive and specific detection of target PD1/PD-L1.
Enabling the visualisation of PD1/PD-L1 in the tissue micro-environment, these kits are ideal for applications in cancer research studies including; predictive biomarker discovery, patient stratification and treatment validation.
Find out more about Naveni proximity ligation technology.
Benefits of using these PD1/PD-L1 assay kits
• Ideal for the detection of low abundant proteins
• Consistency in staining
• High specificity
• High signal-to-noise ratio
• Simple protocol based on secondary detection using Navenibodies
• Utilises bright-field read-out
• Detection with HRP/AP substrate
• Compatible with FFPE samples
Proximity Ligation assay detection of PD1/PD-L1 interaction and phosphorylated PD1
Left: Protein-protein interaction (PPI): Proximity Ligation assay for detection of PD1/PD-L1 interaction. Right: Protein post-translational modifications (PTM): Proximity Ligation assay for detection of phosphorylated PD1.
Material available for download
Poster: Detection of the proximity of PD1/PD-L1 in human FFPE tissues
Poster: Development of a chromogenic in situ Proximity Ligation assay
Naveni PD1/PD-L1 product sheet
Naveni pY PD1 product sheet
Note: product availability depends on country - see product detail page.