Highly specific MHC multimers

This range of highly specific and novel fluorescent MHC multimers from JPT Peptide Technologies can be used to detect, isolate and quantify antigen-specific T cells. Utilising a dextran polymer backbone with a greater number of associated MHC molecules and an increased number of fluorochromes than standard MHC multimers, the MHC Dextramers® enable both a higher binding specificity to the T cell of interest and increased levels of staining resulting in an overall increase in both resolution and signal-to-noise ratio. Over 400 different individual MHC I dextramers® are in three colours, covering the human, mouse and monkey alleles are available.

Benefits of using the MHC Dextramers®
• Highly sensitive
• High binding specificity
• Stronger signals
• Reduced background staining
• Increased signal-to-noise ratio
• Custom service available

MHC Dextramers® applications
• Antigen-specific T cells detection and isolation in fluid cell samples by flow cytometry
In vitro staining of tissue sections to visualise antigen-specific T cells
• Antigen-specific T-cell response monitoring during
- Vaccine development
- Immunotherapeutic development
- Clinical trials
• Antigen-specific immune status determination of
- Transplantation patients
- Immunodeficient patients 
- Patients receiving immunosuppressive drugs
• T-cell response profiling in infectious disease, cancer, autoimmunity and other malignancies
• Antigen-specific T-cell response detection in immunological research

MHC Dextramers® formats
1. Individual MHC I Dextramers®
A small selection of the alleles available are shown in the table below but for a full list of individual MHC multimers available, please contact our JPT Peptide Technologies specialist by clicking here

2. MHC I Dextramer® collections
The MHC I Dextramer® collections are composed of selected sets of multimers for monitoring antigen-specific T cell responses for different viruses or types of cancer. Different fluorochromes are available for each multimer collection (APC, PE, FITC) e.g. Melanoma Dextramer® Collection 1 contains six carefully selected melanoma specific MHC I Dextramers® (+ one control).

3. Custom MHC I Dextramers®
A custom MHC I Dextramer® service is also available. To discuss a custom multimer project with our JPT Peptide Technologies specialist, please click here.

MHC Dextramers® citation list

 

Products

Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
EBV Dextramer Package 1-APC RX05-APC · JPT Peptide Technologies
RX05-APC
JPT Peptide Technologies
4 x 50 tests £4820.00
4 x 50 tests
view
Virus Dextramer Collection 1-APC RX03-APC · JPT Peptide Technologies
RX03-APC
JPT Peptide Technologies
5 x 50 tests £5913.00
5 x 50 tests
view
Cancer-Testis Antigens Dextramer Collection 1 RX02 · JPT Peptide Technologies
RX02
JPT Peptide Technologies
8 x 25 tests £5856.00
8 x 25 tests
view
Melanoma Dextramer Collection 1 RX01 · JPT Peptide Technologies
RX01
JPT Peptide Technologies
12 x 25 tests (plus 2 negative controls) £9963.00
12 x 25 tests (plus 2 negative controls)
view
CMV Dextramer Package 1-PE CMV-PACK-PE · JPT Peptide Technologies
CMV-PACK-PE
JPT Peptide Technologies
9 x 50 tests £9160.00
9 x 50 tests
view
EBV Dextramer Package 1-FITC RX05-FITC · JPT Peptide Technologies
RX05-FITC
JPT Peptide Technologies
4 x 50 tests £4820.00
4 x 50 tests
view
Virus Dextramer Collection 1-FITC RX03-FITC · JPT Peptide Technologies
RX03-FITC
JPT Peptide Technologies
5 x 50 tests £5913.00
5 x 50 tests
view
CMV Dextramer Package 1-APC CMV-PACK-APC · JPT Peptide Technologies
CMV-PACK-APC
JPT Peptide Technologies
9 x 50 tests £9160.00
9 x 50 tests
view
EBV Dextramer Package 1-PE RX05-PE · JPT Peptide Technologies
RX05-PE
JPT Peptide Technologies
4 x 50 tests £4820.00
4 x 50 tests
view
Virus Dextramer Collection 1-PE RX03-PE · JPT Peptide Technologies
RX03-PE
JPT Peptide Technologies
5 x 50 tests £5913.00
5 x 50 tests
view
CMV Dextramer Package 1-FITC CMV-PACK-FITC · JPT Peptide Technologies
CMV-PACK-FITC
JPT Peptide Technologies
9 x 50 tests £9160.00
9 x 50 tests
view