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DNA/RNA Shield

DNA/RNA Shield from Zymo Research is a DNA and RNA stabilisation solution for nucleic acids in any biological sample. DNA/RNA Shield preserves the genetic integrity and expression profiles of samples at ambient temperatures and completely inactivates infectious agents (viruses, bacteria, fungi, & parasites). This unique DNA and RNA stabilization solution also prevents degradation from freeze-thaw cycling and unexpected freezer failures.

Benefits of using DNA/RNA Shield
• CE marked bulk reagents
• Preserves RNA integrity
• Deactivates pathogens (viruses, bacteria, fungi and parasites )
• Safe, room temperature, shipping and handling
• Compatible with most RNA extraction kits, without reagent removal

Worldwide use
DNA/RNA Shield is in use in numerous NHS and private testing labs in the UK as well as globally in public and private molecular diagnostics labs. More information can be found here

Zymo Research COVID antigen testing FDA EUA workflow
DNA/RNA Shield is a key component of the Zymo Research COVID antigen testing workflow, which has been granted an EUA by the FDA. More information can be found here.

Pathogen inactivation
DNA/RNA Shield has been rigorously tested for its ability to deactivate a wide range of pathogens, including MERS coronavirus, Ebola and M. tuberculosis, without the need for additional steps, such as heat-treatment, homogenisation or alcohol sterilisation. In an independent study, the virucidal activity was shown to inactivate murine parvovirus1. DNA/RNA Shield abides by the Center for Disease Control’s (CDC) guidelines for pathogen inactivation2.

Inactivation of SARS-CoV-2 with DNA/RNA Shield

Pathogen type Species inactivated
Viruses MERS-coronavirus, Parvovirus, Chikungunya virus, Dengue virus, Ebola virus, Herpes simplex virus-1, Herpes simplex virus-2, Influenza A, Rhinovirus, West Nile virus
Bacteria B. subtilis, E. faecalis, E. coli, L. fermentum, L. monocytogenes, M. tuberculosis, P. aeruginosa, S. enterica, S. aureus, S. pneumoniae, X. fastidiosa
Yeast and eukaryotes C. albicans , C. neoformans , S. cerevisiae , P. malariae


1. Dr. Thraenhart and Dr. Jursch. Virucidal activity of the nucleic acid preservation product “DNA/RNA Shield™” against the murine parvovirus (MVM) at 20 °C. 
2. Guidance on the inactivation or removal of select agents and toxins for future use. Center for Disease Control (CDC)

Material available for download
DNA/RNA Shield: For safe, effective COVID-19 surveillance
DNA/RNA Shield swab collection kit protocol
DNA/RNA Shield protocol
Eurovir® DNA/RNA Shield test report
DNA/RNA Shield inactivation citations
DNA/RNA Shield COVID-19 inactivation declaration
Inactivation of SARS-CoV-2 with DNA/RNA Shield

Free samples
Request a free DNA/RNA Shield sample

Zymo Research has filed for Emergency Use Authorisation (EUA) w/ the FDA for its collection, extraction, and RT-PCR workflow for COVID-19 Testing.


Note: product availability depends on country - see product detail page.

Details Cat number & supplier Size Price
DNA/RNA Shield R1100-50 · Zymo Research
Zymo Research
50 ml £82.00
50 ml
DNA/RNA Shield R1100-250 · Zymo Research
Zymo Research
250 ml £281.00
250 ml