The Cardiosight-S® from Nexel are pure, electrophysiologically active populations of cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs). Providing more reliable cardiac toxicity screening, the novel cells can be cultured more consistently than primary cells enabling improved human cardiotoxicity predictions compared to models using animal-derived cells.
Cardiomyocyte marker expression
Cardiosight-S expresses cardiomyocyte markers (cTnT,α-actinin)
Highly pure population of cardiomyocytes (cTnT ≥ 95%)
Expression level of ion channel marker genes
Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner
E-4031 treated - Field potential duration (FPD) reading using microelectrode array (MEA) corresponds to prolongation of QT interval of electrocardiogram. Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner.
• Cardiac toxicity testing
• Drug screening
• 3D printing
• Electrophysiological & biochemical assays
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