Amyloid & HFIP-treated amyloid peptides

Bachem provides more than 190 Alzheimer’s Disease related products including Aβ 42 peptides, Aβ 40 peptides, Aβ 40/42 mutants peptides, Aβ 25-35 peptides, modifiers of Aβ, aggregation peptides and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)-treated peptides. Treating with HFIP is a standard method to disrupt amyloid fibrils, removing the coiling and generating Aβ monomers.

Benefits of using these amyloid peptides
• Variety of options available
• HFIP-treated amyloid β-peptides 1-40 and 1-42 available
• 0.1 mg to bulk pack sizes available
• Large quantities of single batch peptide available
• More than 6,500 catalogue products

 

HFIP-treated amyloid β-peptide (1-42) H7442 and amyloid β-peptide (1-40) H-7438 obtained by dissolving corresponding Aβ-peptides H-1368 and H-1194 in HFIP, aliquoting and removing solvent as described in literature. Morphology of resulting peptides studied by transmission electron microscopy (TEM). Samples of both peptides reconstituted in ultrapure water at 10 mg/ml and incubated a 37ºC for 20 h. 20 µl aliquots each sample applied to Formvar-coated copper grids for 5 min adsorption followed by washing step (floating on water drop). Peptide-treated grids stained with 2% aqueous uranyl acetate. TEM studies of amyloid fibril formation by Solvias AG using ZEiss EM 910 at 100 kV. Images of growing β-amyloid fibrils taken by digital camera. Magenta arrow points to nucleation centres where aggregation starts, yellow arrow indicates fibrils formed as long thin helical structures with regular twists.

HFIP-Treated Amyloid citation list

A small selection of products available are shown below. Please use our website search or contact our Bachem specialist Here, for a full list of products.

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