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Direct-Zol DNA/RNA

DNA/RNA Shield™ Microbial Pathogen Sample Collection Tubes

Complex siRNA Pools For Gene Silencing

Highly effective & efficient in vitro delivery of Cas9 RNP for genome editing in challenging cells

Ribosomal RNA Depletion - riboPOOL

Ribosomal RNA Depletion - riboPOOL

Cambridge Bioscience offers an affordable and flexible solution for ribosomal RNA (rRNA) depletion or other custom RNAs from any species.  Composed of high complexity pools of optimally-designed biotinylated DNA probes, riboPOOLs allow the efficient removal of abundant rRNAs from total RNA samples isolated from prokaryotic or eukaryotic cells or tissues. 

Benefits Of Using riboPOOL
• Highly efficient & specific
• Any species
• Low cost solution
• Deplete custom RNA
• Applicable for non-polyadenylated RNA
• Custom scales available

riboPOOL Workflow

riboPOOL Workflow

riboPOOL Technology
riboPOOLs consist of complex mixtures of single-stranded 3’biotinylated oligonucleotide-probes designed to specifically hybridise with all ribosomal RNAs of the target species. Ribosomal RNAs bound to riboPOOL-probes are efficiently removed from the samples by streptavidin-conjugated magnetic beads. riboPOOLs work independent of RNA polyadenylation and can be applied for any downstream application e.g. NGS library preparation.

riboPOOL Formats

riboPOOL

In Silico Validated

Experimentally Validated

Human
ü
ü
Mouse/Rat
ü
ü Mouse
Planarian
ü
ü
Pan-prokaryote (designed against 76 representative species from all common bacteria/archaebacterial phyla)
ü
ü (S.aureus, E.coli, Salmonella, Helicobacter, Fusobacterium, Campylobacter, Vibrio, C.difficile)
Yeast (S.cerevisiae)
ü
 
Drosophila
ü
 
Plant (Arabidopsis Thaliana)
ü
 
Globin (mRNA)
ü
 
E.coli
ü
 
S.Aureus
ü
 
B.Subtilis
ü
 
P.Aeruginosa
ü
 
S.Enterica
ü
 
Stenotrophomonas sp.
ü
 

Material Available For Download
riboPOOL Brochure
Pan-Prokaryote riboPOOL Flyer

Ribo-Zero is a trademark of Illumina, Inc

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Contact Our siTOOLs Biotech Specialist, Doaa

siTOOLs Biotech