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Long Read Transcriptome Sequencing From Illumina Sequencers
3D Collagen Matrix Cell Contraction Assay

Frozen Human Plasma

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Cardiomyocytes from hiPSCs - Cardiosight-S®

Cardiomyocytes from hiPSCs - Cardiosight-S®

Nexel's Cardiosight-S® are pure populations of cardiomyocytes, derived from human induced pluripotent stem cells (hiPSCs) which provides more reliable cardiac toxicity screening, enabling improved human cardiotoxicity predictions compared to models using animal-derived cells. The novel Cardiosight-S® cardiomyocytes can be cultured more consistently than primary cells.

Cardiomyocyte marker expression

Cardiomyocyte marker expression - Cardiosight-S®

Cardiosight-S expresses cardiomyocyte markers (cTnT,α-actinin)

Highly pure population of cardiomyocytes (cTnT ≥ 95%)

Cardiosight-S is a highly pure population of cardiomyocytes (cTnT ≥ 95%)

Expression level of ion channel marker genes

Cardiosight-S® - Expression Levels Of Ion Channel Marker Genes

Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner

Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner.

E-4031 treated - Field potential duration (FPD) reading using microelectrode array (MEA) corresponds to prolongation of QT interval of electrocardiogram. Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner.

Applications
• Cardiac toxicity testing
• Drug screening
• 3D printing
• Lab-on-a-chip
• Electrophysiological & biochemical assays

Cardiosight-S® citations

Material available for download
Cardiosight-S® User Guide
Cardiosight-S® MSDS

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