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Unique Cell Separation Technology

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mRNA Based Live Cell Staining Solution

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Cardiomyocytes From hiPSCs - Cardiosight-S®

Cardiomyocytes From hiPSCs - Cardiosight-S®

Cambridge Bioscience offers pure populations of cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) for more reliable cardiac toxicity screening. Enabling improved human cardiotoxicity predictions compared to models using animal-derived cells, the novel Cardiosight-S® cardiomyocytes can be cultured more consistently than primary cells.

Cardiomyocyte marker expression

Cardiomyocyte marker expression - Cardiosight-S®

Cardiosight-S expresses cardiomyocyte markers (cTnT,α-actinin)

Highly pure population of cardiomyocytes (cTnT ≥ 95%)

Cardiosight-S is a highly pure population of cardiomyocytes (cTnT ≥ 95%)

Expression level of ion channel marker genes

Cardiosight-S® - Expression Levels Of Ion Channel Marker Genes

Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner

Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner.

E-4031 treated - Field potential duration (FPD) reading using microelectrode array (MEA) corresponds to prolongation of QT interval of electrocardiogram. Cardiosight-S demonstrates physiological response to ion-channel blockers in a dose-dependent manner.

Applications
• Cardiac toxicity testing
• Drug screening
• 3D printing
• Lab-on-a-chip
• Electrophysiological & biochemical assays

Cardiosight-S® Citations

Material Available For Download
Cardiosight-S® User Guide
Cardiosight-S® MSDS

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