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Highly Specific Neuroscience PrecisA Marker Portfolio

Highly Specific Neuroscience PrecisA Marker Portfolio

Cambridge Bioscience offers a highly specific and selective neuroscience marker portfolio targeting anatomical and neurochemical cell types in human and rodent nervous systems. Consisting of 34 PrecisA mouse monoclonals™ produced under stringent conditions that recognise only unique non-overlapping epitopes and/or isotopes, this portfolio includes neural lineage markers (for neurons, astrocytes and oligodendrocytes/Schwann cells) and signalling markers (targeting glutamate, GABA, acetylcholine, noradrenaline, dopamine and serotonin systems). Different antibody isotypes are also available allowing for multiplexing.

Benefits Of Using This Neuroscience Marker Portfolio
• High specificity & selectivity for target proteins
• Selected target proteins expressed by single cell type
• IHC validation in rat, mouse & human tissues
• WB validation in mouse & human tissues for majority of markers
• Different isotypes available allowing for multiplexing
• Antigen used & epitope information provided (epitope mapped)
• Developed under stringent conditions for PrecisA Monoclonals™

Multiplexed IHC-IF staining of a coronal section of rat brain visualising neurons in green, olygodendrocytes in magenta and astrocytes in red. Anti-NEFM antibody of isotype IgG2b (AMAb91030 is used to show neurons and their processes, olygodendrocytes are detected by Anti-CNP antibody of isotype IgG2a (AMAb91068) and astrocytes by Anti-GFAP antibody of isotype IgG1 (AMAb91033).
 

Left: Multiplexed IHC-IF staining of sagittal mouse brain section showing the GABAergic system in red, glutamatergic system in green and acetylcholine system in magenta. The Anti-GAD1 antibody of isotype IgG2a (AMAb91076) is used as marker for the GABAergic system, Anti-VGLUT1 antibody of isotype IgG2b (AMAb91041) for the glutamatergic system and Anti-CHAT antibody of isotype IgG1 (AMAb91129) is used to visualise the acetylcholine system. Right: High-power image demonstrates the three systems in the basal forebrain (corpus striatum/globus pallidus), using the same antibodies.

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Contact Our Atlas Antibodies Specialist, Hiten