Supplier information: BioLegend
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Announcing the launch of BioLegend UK BioLegend develops and manufactures world-class, cutting-edge antibodies and reagents for biomedical research. Cambridge Bioscience is pleased to support the launch of BioLegend UK, a wholly owned subsidiary of BioLegend Inc. Under the new arrangement BioLegend customers will benefit from:
U.K-based customers should continue to place orders as before to Cambridge Bioscience directly by phone (01223 316855), fax (01954 781323), or e-mail sales@bioscience.co.uk) or via your institution’s procurement system. Helios is a transcription factor belonging to the Ikaros family of Zinc-finger proteins. While its mechanism of action is still poorly understood, Ikaros family members are believed to regulate transcription by chromatin remodelling.
Thornton, AM., et al. 2010 J. Immunol. 0904028.PubMed Ordering information
Other Treg Resources
Other Treg Reagents from BioLegend  PerCP/Cy5.5 Anti-human LAP (TGF-β1) PE Anti-mouse CD223 (LAG-3) LEAF™ Purified Anti-mouse FR4 Pacific Blue™ Anti-human FOXP3 PE Anti-mouse/rat/human FOXP3 Alexa Fluor® 488 Anti-human FOXP3 Flow Kit One Step Staining Mouse Treg Flow™ Kit (CD4, CD25, FOXP3) The program death 1 receptor (PD-1, also known as CD279) in an inhibitory receptor that plays a key role in peripheral tolerance and autoimmune disease. PD-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) in the cytoplasmic region. CD279/PD-1 is expressed predominantly on activated T cells, B cells, and the myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279/PD-1 and are members of the B7 gene family. Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on same normal tissue and upregulation on activated antigen-presenting cells. Interaction of CD279: PD-Ligands result in inhibition of T cell proliferation and cytokine secretion.
 Interleukin 22 (IL-22) is involved in inflammatory and wound healing processes. IL-22 is produced mostly by IL-17-producing helper T cells. Recently, a new IL-22-producing human helper T cell population, Th22, has been described, distinct from both Th17 cells and Th1 cells. Th22 cells may be important in skin homeostasis and pathology. BioLegend offer a range of products to study IL-22: Reference: Trifari, S. et al. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from Th-17, Th1 and Th2 cells. 1: Nat Immunol. 2009 Aug;10(8):864-71. PubMed  |
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