ECM Cell Adhesion Assays
Cell adhesion is an important process for cell migration, invasion, embryogenesis, wound healing and tissue remodelling. The term applies to both cell-to-cell adhesion as well as cellular-matrix interactions and is mediated by cell adhesion molecules such as selectins, cadherins and integrins. Cellular adhesion is often dysregulated during carcinogenesis as tumour cells develop their metastatic capabilities to bind vascular endothelium and extracellular matrix in remote locations.
Cambridge Biosciences offers the CytoSelect™ 48-Well Extracellular Matrix Protein (ECM) Cell Adhesion Assays. These assays provide a fully quantitative, simple method for the evaluation of cell adhesion, requiring no manual cell counting. Both fluorometric and colourimetric detection formats are available.
Simple Protocol
1. Cells are seeded onto a plate pre-coated with a selected ECM substrate including collagen I, collagen IV, fibrinogen, fibronectin, laminin or an array containing all five
2. Non-adherent cells are then washed away
3. Remaining cells are quantified via a colourimetric or fluorometric plate reader.
To find out more about our range of endothelium and epithelium adhesion assays, please Click Here
Products
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