PRIMA-1
Catalogue number:
CAY63520-10 mg
Supplier:
Size:
10 mg
Product is available in:
£147.00
Estimated delivery Thu 18 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
5608-24-2
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C9H15NO3
Molecular Weight:
185.2
Alternative Names:
2,2-
- MSDS: View or download
Product Description:
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
