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[Pyr3]-beta-Amyloid (3-40), Human - ANA29906-1 - 1 mg - AnaSpec - proteins & peptides

[Pyr3]-beta-Amyloid (3-40), Human
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Size: 1 mg
£494.00
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Catalogue number:
ANA29906-1
Name:
[Pyr3]-beta-Amyloid (3-40), Human
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This peptide triggers the formation of insoluble Aß peptide deposits, inhibits secretion of amyloid protein precursor (APP) and increases cell-associated APP. The fibrils in the plaques formed in the brains of patients with Alzheimer’s disease contain significant amounts of truncated Aß proteins such as Aß(3-40) and Aß (11- 40). These two fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate.

Data sheet:

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Product Type:
Proteins & Peptides
Alternative Names:
Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Storage Temp:
-20°C
Molecular Weight:
4125.7
Reference:
Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000); Russo, C. et al. Nature. 405, 531 (2000).
UNSPSC Code:
12352202