www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Neurotensin (8-13)

Catalogue number:
Supplier:
Size:
5 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£237.00 Estimated delivery Thu 4 Apr
Shipping is calculated in checkout
CAS Number:

60482-95-3

Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

817

Product Description:

Neurotensin is a 13 amino acid neuropeptide first isolated from bovine hypothalamus. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract, where it induces smooth muscle contraction. In the CNS, neurotensin has a dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.
The intrastriatal perfusion with Neurotensin (1-13) [NT(1-13)] and its active fragment NT(8-13) on striatopallidal GABA leads to the increased striatal and pallidal GABA release, and this effect is antagonized by intrastriatal perfusion with the NT receptor antagonist. In other experiments, NT, NT (8-13) and [D-Tyr(11)] NT are applied into the ventral tegmental area on extracellular dopamine in the prefrontal cortex and nucleus accumbens of rats. In the prefrontal cortex, neurotensin (8-13) is as potent as neurotensin but ineffective in [D-Tyr(11)]neurotensin. In the caudal nucleus accumbens, neurotensin (8-13) and neurotensin appears more potent than [D-Tyr(11)]neurotensin. In contrast, in the rostral nucleus accumbens, neurotensin(8-13) is less potent than [D-Tyr(11)]neurotensin and neurotensin.

Storage Temperature:

-20°C

Details Cat number & supplier Size Price
HOE I40 ANA22968 · AnaSpec
ANA22968
AnaSpec
1 mg £214.00
1 mg
view
[Des-Arg10]-HOE I40 ANA22970 · AnaSpec
ANA22970
AnaSpec
1 mg £214.00
1 mg
view
GRGESP ANA22950 · AnaSpec
ANA22950
AnaSpec
5 mg £276.00
5 mg
view
Neurotensin 10 mg ANA22985 · AnaSpec
ANA22985
AnaSpec
10 mg £296.00
10 mg
view
GRGDTP ANA22948 · AnaSpec
ANA22948
AnaSpec
5 mg £276.00
5 mg
view
HCV Protease FRET Substrate ANA22991 · AnaSpec
ANA22991
AnaSpec
1 mg £1075.00
1 mg
view
GRGDSP ANA22946 · AnaSpec
ANA22946
AnaSpec
5 mg £193.00
5 mg
view
HCV Protease FRET Substrate 0.25mg ANA22991-025 · AnaSpec
ANA22991-025
AnaSpec
0.25 mg £335.00
0.25 mg
view
GRGDSP ANA22945 · AnaSpec
ANA22945
AnaSpec
1 mg £61.00
1 mg
view
HIV Protease FRET SubstrateI ANA22992 · AnaSpec
ANA22992
AnaSpec
1 mg £429.00
1 mg
view