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Big Gastrin-1, human

Catalogue number:
Supplier:
Size:
0.5 mg _$$_
Product is available in:
  • UK
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£481.00 Estimated delivery Thu 4 Apr
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CAS Number:

60675-77-6

Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

3849.5

Product Description:

Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Storage Temperature:

-20°C

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