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Big Gastrin-1, Human - ANA20747 - 0.5 mg - AnaSpec - proteins & peptides

Big Gastrin-1, Human
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Size: 0.5 mg
£333.00
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Catalogue number:
ANA20747
Name:
Big Gastrin-1, Human
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Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin - Cat# AS-20750). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Data sheet:

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Product Type:
Proteins & Peptides
Alternative Names:
Pyr-LGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF-NH2
Storage Temp:
-20°C
Compound Purity:
% Peak Area By HPLC ≥95%
Molecular Weight:
3849.3
Reference:
Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980)Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x.O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848Dockray, G. et.al. Pflügers Archiv 449,344 (2005)Bundgaard, JR. et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334
UNSPSC Code:
12352202