JNK Antibody
Catalogue number:
3701-100
Supplier:
BioVision
Size:
100 µg _$$_
Product is available in:
N/A
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This product is no longer available to order.
Applications:
Western blot, Immunoprecipitation, Immunohistochemistry
Antibody Host:
Rabbit
Species Reactivity:
Human, mouse, rat
Antibody Isotype:
Rabbit IgG
Antibody Type:
Polyclonal
Immunogen:
Synthetic peptide surrounding amino acid 412 of human JNK-1
- Data sheet: View or download
Product Description:
The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-α and IL-1), UV light, inhibitors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). JNK binds tightly to the N-terminal region of c-Jun and ATF-2, and phosphorylates c-Jun at Ser63 and Ser73 and ATF-2 at Thr69 and Thr71.
Storage Temperature:
-20°C