PARP Antibody
Catalogue number:
3002-100
Supplier:
BioVision
Size:
100 µg _$$_
Product is available in:
N/A
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This product is no longer available to order.
Applications:
Western blot
Antibody Host:
Rabbit
Species Reactivity:
Human
Antibody Isotype:
Rabbit IgG
Antibody Type:
Polyclonal
Immunogen:
Synthetic peptide corresponding to caspase cleavage site in human PARP
- Data sheet: View or download
Product Description:
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Storage Temperature:
-20°C
