Vasopressin Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following vasopressin receptor targets:
V1a
Validated Assay/Platform: Binding & Calcium
Description: The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V1a receptors have been shown to be expressed in vascular smooth muscle, hepatocytes, various blood cells, brain, and retina. These receptors mediate cell proliferation, platelet aggregation, coagulation factor release and glycogenolysis. This cell line is useful for both radioligand binding and for functional assays.
V1b
Validated Assay/Platform: Binding & Calcium
Description: The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V1b receptors are expressed in the anterior pituitary where they mediate ACTH release. Selective V1b antagonists have been shown to have anxiolytic and antidepressant effects. This cell line is useful for both radioligand binding and for functional assays.
V2
Validated Assay/Platform: Binding & Calcium
Description: The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V2 receptors are expressed in kidney where vasopressin exerts its antidiuretic action.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here
Request A No Obligation Quote
To discuss a GPCR screening project, please contact our experienced team by Clicking Here
