Transdifferentiation (TD) is the direct conversion of one cell type to another. This reprogramming method provides a rapid route for creating novel cell types and manufacturing functional tissues. TD enables the generation of patient-specific cell types without the risk of creating potentially tumourigenic induced pluripotent stem cells before differentiation. These vectors allow researchers to take a cell-type such as fibroblasts and directly convert them into another, for example neuronal cells as in Wernig et al., Nature 2010.
Cambridge Bioscience offers collections of transcription factors and microRNAs built in constitutive or inducible vector formats from the TD Consortium via SBI to reprogram cell lineages.
Clone Formats Available
The following clone formats are available:
• Constitutive Lentivector expression
• Inducible Lentivector expression
• Minicircle nonviral vector expression
Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010 Feb 25;463(7284):1035-41.
To find out more about this range of transdifferentiation factors, please click on the links below.