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Comprehensive Epigenetic Profiling and Screening Services
Ion Channel Screening & Profiling Services
Broad Spectrum Lipid Metabolism Assay Portfolio

Sodium, Voltage-Gated Channels

Cambridge Bioscience, through our collaboration with B'SYS, offers access to screening services for the following voltage-gated sodium channel targets:

Nav1.1
Gene Name: SCN1A
Description: The human SCN1A gene encodes the pore-forming subunit of Nav1.1, a voltage-gated sodium channel expressed in CNS neurons and dorsal root ganglia. Mutations in SCN1A cause several types of epilepsies (generalised epilepsy with febrile seizures, severe myoclonic epilepsy in infancy) and some forms of familial hemiplegic migraine. Nav1.1 channels are therapeutic targets in seizure, stroke and pain.

Nav1.2
Gene Name: SCN2A
Description: The human SCN2A gene encodes the pore-forming subunit of Nav1.2, a voltage-gated sodium channel expressed in CNS neurons. SCN2A mutations are associated with benign familial neonatal-infantile seizures. Nav1.2 channels are therapeutic targets in seizure, stroke and pain.

Nav1.3
Gene Name: SCN3A
Description: The human SCN3A gene encodes the pore-forming subunit of Nav1.3, a voltage-gated sodium channel expressed in CNS neurons and upregulated in nerve injury. Nav1.3 channels are therapeutic targets in seizure and pain.

Nav1.5
Gene Name: SCN5A
Description: The human SCN5A gene encodes the pore-forming subunit of Nav1.5, a voltage-gated sodium channel expressed in heart and upregulated in breast cancer cells. Mutations in SCN5A are responsible for some forms of long QT and short QT syndromes, progressive cardiac conduction defect, sick sinus node syndrome, and dilated cardiomyopathy, Brugada syndrome, congenital heart block, Nav1.5 channels are anti-targets in cardiac risk assessment.

Nav1.6
Gene Name: SCN8A
Description: The human SCN8A gene encodes the pore-forming subunit of Nav1.6, a voltage-gated sodium channel expressed in central and peripheral nervous systems. Mutations in the mouse ortholog cause ataxia and other movement disorders. Nav1.6 channels are therapeutic targets in multiple sclerosis and seizure.

Nav1.7
Gene Name: SCN9A
Description:
The SCN9A gene encodes the alpha subunit of the type IX voltage gated sodium channel NaV1.7. Mutations in this channel are associated with primary erythromelalgia, insensitivity to pain and paroxysmal extreme pain disorder, making it a significant target in therapeutic pain treatment and nociceptive disorders.

Nav1.8
Gene Name: SCN10A
Description: The human SCN10A gene encodes the pore-forming subunit of Nav1.8, a voltage-gated sodium channel expressed in the peripheral nervous system including dorsal root ganglia. Nav1.8 channels are upregulated in chronic/inflammatory pain and are therapeutic targets in pain treatment.

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