Serotonin Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following serotonin receptor targets:
5HT1A
Synonym: HTR1A
Validated Assay/Platform: Binding & cAMP
Description: Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5-HT1 to 5-HT7). Among them, 5-HT1a receptors are expressed mainly in the CNS where they induce neuronal inhibition and control behavior, such as sleep, food intake, thermoregulation, aggression, and anxiety. This receptor has been used as a target for developing drugs to treat anxiety and depression.
5HT2B
Synonym: HTR2B
Validated Assay/Platform: Calcium
Description: Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5-HT1 to 5-HT7). 5-HT2B receptors are expressed in the liver, kidney, lung, heart, pancreas, spleen, brain, spinal cord, gastrointestinal tract, placenta, and coronary and pulmonary arteries. It has also been reported in embryonic mouse heart. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome.
5HT2b
Synonym: HTR2B
Validated Assay/Platform: Binding & cAMP
Description: Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2b receptors are expressed in the brain, vasculature, smooth muscle, uterus, and stomach. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome
5HT2c
Synonym: HTR2C
Validated Assay/Platform: Binding
Description: Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2c receptors are expressed in brain and choroid plexus. This receptor has been used as a target for developing drugs to treat migraine and obesity.
5HT4
5-HT6
Synonym: HTR6
Validated Assay/Platform: Binding
Description: Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5-HT6 receptor is expressed in several human brain regions, most prominently in the caudate nucleus. It is positively coupled to adenylcyclase and has pharmacological properties with high affinity for several therapeutically important antidepressant and antipsychotic drugs, in particular the atypical antipsychotic clozapine and related compounds.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
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