Purinergic Receptor Channels

Cambridge Bioscience, through our collaboration with ChanTest, offers access to screening services to the following ionotropic purinergic receptor channel targets:

P2X1
Gene Name: P2RX1
Validated Assay/Platform: FLIPR®
Description: The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation. P2X1 receptors are therapeutic targets in treatment of urinary incontinence and pain.

P2X2
Gene Name: P2RX2
Validated Assay/Platform: FLIPR® & QPatch HT
Description: The human P2RX2 gene encodes P2X2, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS and dorsal root ganglion neurons. P2X2 channels are therapeutic targets in treatment of pain.

P2X2/P2X3
Gene Name: P2RX2/P2RX3
Validated Assay/Platform: FLIPR®
Description: The human P2RX2 AND P2RX3 genes encode P2X2/P2X3, aheteromeric ionotropic ATP receptor that functions as an ATP-activated cation channel cation channel expressed in CNS and dorsal root ganglion neurons. P2X2/P2X3 receptors expressed in neurons are therapeutic targets in treatment of pain.

P2X3
Gene Name: P2XR3
Validated Assay/Platform: FLIPR®
Description: The human P2RX3 gene encodes P2X3, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in spinal cord and sensory neurons. P2X3 receptors are therapeutic targets in treatment of neuropathic and inflammatory pain, inflammatory bowel disease, urinary incontinence, and cough.

P2X4
Gene Name: P2RX4
Validated Assay/Platform: FLIPR®, PatchXpress® & QPatch HT
Description: The human P2RX4 gene encodes P2X4, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS, alveolar macrophages, vascular endothelium, and airway smooth muscle. P2X4 receptors are therapeutic targets in treatment of neuropathic pain, asthma, and heart failure.

P2X7
Gene Name: P2RX7
Validated Assay/Platform: QPatch HT
Description: The human P2RX7 gene encodes P2X7, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in lymphocytes and microglia. P2X7 receptors are therapeutic targets in treatment of osteoporosis, neuropathic and inflammatory pain, and immune diseases.

Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to the widest range of screening platforms, from manual patch clamp up to the most recent innovations in automated electrophysiology, allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here

Request A No Obligation Quote
To discuss an ion channel screening project, please contact our experienced team by Clicking Here