Potassium, Calcium-Activated Channels
Cambridge Bioscience, through our collaboration with ChanTest, offers access to screening services to the following calcium-activated potassium channel targets:
BK (KCa1.1)
Gene Name: KCNMA1
Validated Assay/Platform: PatchXpress®
Description: The human KCNMA1 gene encodes the pore-forming subunit of KCa1.1, a calcium-activated BK potassium channel. KCa1.1 channels, widely distributed, are therapeutic targets in stroke, seizure, urinary incontinence, asthma, hypertension, gastric dysmotility, schizophenia, and prostate cancer.
IK (KCa3.1)
Gene Name: KCNN4
Validated Assay/Platform: PatchXpress® & QPatch HT
Description: The human KCNN4 gene encodes the pore-forming subunit of KCa3.1, the calcium-activated IK potassium channel. KCa3.1 channels expressed in lymphocytes, fibroblasts, proliferating vascular smooth muscle cells, vascular endothelium and, intestinal and airway epithelia are therapeutic targets in inflammatory diseases in these tissues. KCa3.1 channels expressed in erthrocytes have been investigated as targets for treatment of sickle cell anemia
SK1 (KCa2.1)
Gene Name: KCNN1
Validated Assay/Platform: Manual Patch Clamp
Description: The KCNN1 gene encodes the pore-forming subunit of a small-conductance (2 - 3 pS single channel conductance), K+-selective, channel that is activated by increased intracellular [Ca2+]. Expressed in neurons, hKCa2.1 channels contribute to the afterhyperpolarization that modulates repetitive firing frequency.
SK2 (KCa2.2)
Gene Name: KCNN2
Validated Assay/Platform: FLIPR® & Manual Patch Clamp
Description: The human KCNN2 gene encodes the pore-forming subunit of KCa2.2, the calcium-activated, voltage-gated SK2 potassium channel. KCa2 channels are responsible for afterhyperpolarization that regulates neuronal repetitive excitation. KCa2.2 channels expressed in CNS neurons are therapeutic targets in neurologic disorders (e.g., cognitive impairment and seizure).
SK3 (KCa2.3)
Gene Name: KCNN3
Validated Assay/Platform: FLIPR®
Description: The human KCNN3 gene encodes the pore-forming subunit of KCa2.3, the calcium-activated, voltage-gated SK3 potassium channel. KCa2 channels are responsible for afterhyperpolarization that regulates neuronal repetitive excitation. KCa2.3 channels expressed in CNS neurons are therapeutic targets in neurologic disorders (e.g., cognitive impairment and seizure).
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to the widest range of screening platforms, from manual patch clamp up to the most recent innovations in automated electrophysiology, allowing you to select the right balance of speed, throughput and data quality to suit your needs.
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