Oxidative Stress in Cancer
Oxidative stress is very important in cancer. Oxidative stress is produced in the form of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide which are continually produced during metabolic processes. Excess ROS can lead to cellular injury in the form of damaged DNA, RNA, lipids and proteins. If oxidative damage sites are left unrepaired, this can lead to mutations and changes in cell biology which can lead to neoplasia. Additionally, cancers can and do survive in low oxygen environments which have further implications for tumourigenesis and treatment.
Cambridge Bioscience offers a range of research tools for studying ROS, antioxidants and oxidative lipid, protein and DNA damage.