Oxidative Protein Damage

Proteins within cells will undergo oxidative stress in the presence of various reactive oxygen species (ROS). The resulting damage to the protein may take the form of nitration or oxidation of various residues, depending on the the ROS present.

ROS may also result in the formation of advanced oxidation protein products (AOPP) or advanced glycation end products (AGE), both of which are stable markers of oxidative stress.

Cambridge Bioscience offers Protein Carbonyl Assays and Protein Nitration Assays. These assays provide a quick, sensitive method for detection of carbonyl residues and 3-nitrotyrosine residues, respectively.

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