Oxidative Lipid Damage
ROS attaching to lipids induces lipid peroxidation and subsequent alteration of the mitochondrial respiratory chain. This event in turn reinforces ROS production. Furthermore, the lipid peroxidation product aldehyde 4-HNE, is highly reactive and stimulates additional ROS formation and DNA damage. Thus, ROS activate mutagenic events associated with carcinogenesis.
Cambridge Bioscience offers a selection of tools to investigate the by-products of these events including isoprostanes and hydroperoxides, MDA (TBARS) and MDA adducts.