ROS attaching to lipids induces lipid peroxidation and subsequent alteration of the mitochondrial respiratory chain. This event in turn reinforces ROS production. Furthermore, the lipid peroxidation product aldehyde 4-HNE, is highly reactive and stimulates additional ROS formation and DNA damage. Thus, ROS activate mutagenic events associated with carcinogenesis. Cambridge Bioscience offers a selection of tools to investigate the by-products of these events including isoprostanes and hydroperoxides, MDA (TBARS) and MDA adducts.
