Oxidative DNA Damage
DNA is arguably the most biologically significant target of oxidative and cellular stress. Continuous DNA damage has been implicated in the age-related development of various cancers. Oxidative attack by the hydroxyl radicals on the deoxyribose moiety causes the release of free bases from DNA, generating strand breaks with various sugar modifications and simple abasic (AP) sites. One of the major forms of damage generated by ROS is AP sites or loss of bases.
Cambridge Bioscience offers a wide range of assays to measure the most common types of oxidative DNA damage in cells.