Orexin Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following orexin receptor targets:
OX1
Synonym: Hcrtr1
Validated Assay/Platform: Binding & Calcium
Description: The orexins (orexin-A and orexin-b) have a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, though orexin-A is equipotent at OX1 and OX2, whilst orexin-B displays a moderate selectivity for OX2.
OX2
Synonym: Hcrtr2
Validated Assay/Platform: Binding & Calcium
Description: The orexins (orexina-A and orexin-b) have a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, though orexin-A is equipotent at OX1 and OX2, whilst orexin-B displays a moderate selectivity for OX2
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here
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