Opioid Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following opioid receptor targets:
Delta
Synonym: Delta, OPRD1
Validated Assay/Platform: cAMP
Description: Opioid receptors are widely distributed in brain, spinal cord and peripheral sensory and autonomic nerves. They are activated physiologically by the products of endogenous opioid peptide genes such as proenkephalin, podynorphin, pro-opiomelancortin and pronociceptin. Four opioid receptor subtypes have been identified including µ, δ, κ, and ORL1. All of these subtypes are coupled to cAMP modulation via Gi/o but each subtype has a distinct pharmacological profile.
Kappa
Synonym: OPRK1
Validated Assay/Platform: cAMP
Description: Opioid receptors are widely distributed in brain, spinal cord and peripheral sensory and autonomic nerves. They are activated physiologically by the products of endogenous opioid peptide genes such as proenkephalin, podynorphin, pro-opiomelancortin and pronociceptin. Four opioid receptor subtypes have been identified including µ, δ, κ, and ORL1. All of these subtypes are coupled to cAMP modulation via Gi/o but each subtype has a distinct pharmacological profile.
Mu
Synonym: Mu, OPRM1
Validated Assay/Platform: cAMP
Description: Opioid receptors are widely distributed in brain, spinal cord and peripheral sensory and autonomic nerves. They are activated physiologically by the products of endogenous opioid peptide genes such as proenkephalin, podynorphin, pro-opiomelancortin and pronociceptin. Four opioid receptor subtypes have been identified including µ, δ, κ, and ORL1. All of these subtypes are coupled to cAMP modulation via Gi/o but each subtype has a distinct pharmacological profile
ORL1
Synonym: OPRL1
Validated Assay/Platform: cAMP
Description: Opioid receptors are widely distributed in brain, spinal cord and peripheral sensory and autonomic nerves. They are activated physiologically by the products of endogenous opioid peptide genes such as proenkephalin, podynorphin, pro-opiomelancortin and pronociceptin. Four opioid receptor subtypes have been identified including µ, δ, κ, and ORL1. All of these subtypes are coupled to cAMP modulation via Gi/o but each subtype has a distinct pharmacological profile.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
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