N-Formyl Peptide Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following n-formyl peptide receptor targets:
FPR1
Validated Assay/Platform: Calcium
Description: The FPR1, FPRL1 and FPRL2 receptors belongs to a family of receptors that all respond to N-formyl peptides. N-Formyl peptides are bacterial peptides which induce chemotaxis in neutrophils and other phagocytic cells to sites of bacterial infection. This cell line allows FPR1 to couple to the intracellular signaling pathway through Ga16, and should be useful for screening compounds for activity as modulators of host defense mechanisms against bacterial infection and in the regulation of inflammatory responses.
FPRL1
Validated Assay/Platform: Binding & Calcium
Description: The FPR1, FPRL1 and FPRL2 receptors belongs to a family of receptors that all respond to N-formyl peptides. N-Formyl peptides are bacterial peptides which induce chemotaxis in neutrophils and other phagocytic cells to sites of bacterial infection.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here
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