Insulin Research Tools

Insulin is a hormone produced by beta cells located in the islets of Langherhans. This hormone is critical for regulating carbohydrate and fat metabolism in the body. The active insulin hormone is produced by proteolytic cleavage of proinsulin by prohormone convertases. Cleavage also results in the release of a short C-peptide sequence that links the two insulin chains, which has also been shown to have an important role in regulating glucose concentration.

Insulin causes cells in the liver, muscle and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. Dysregulation of insulin mediated control of blood glucose concentrations can result in diabetes mellitus. This can be caused by the destruction of the insulin producing beta cells as in the case of Type I Diabetes or by insulin resistance as in Type II Diabetes.

Cambridge Bioscience provides a comprehensive range of ELISA kits for the specific quantification of insulin, proinsulin and C-peptide in mouse and rat samples.

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