Hyperpolarization-Gated Channels

Cambridge Bioscience, through our collaboration with ChanTest, offers access to screening services to the following hyperpolarization-gated channel targets:

HCN1
Gene Name: HCN1
Validated Assay/Platform: PatchXpress®
Description: Human HCN1 hyperpolarization-gated ion channel-expressing, stable replicating cell line.

HCN2
Gene Name: HCN2
Validated Assay/Platform: IonWorks Quattro™, PatchXpress® & QPatch HT
Description: The human HCN2 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN2 channels contribute to pacemaker current that controls rhythmic excitation in the heart and brain.

HCN4
Gene Name: HCN4
Validated Assay/Platform: IonWorks Quattro™ & QPatch HT
Description: The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN4 channels are the predominant HCN isoform in the sinoatrial node and contribute to pacemaker current that controls rhythmic activity in the heart and brain. The HCN4 therapeutic potential includes treatment of cardiac arrhythmia and ischemic heart disease.

Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to the widest range of screening platforms, from manual patch clamp up to the most recent innovations in automated electrophysiology, allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here

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