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Comprehensive Epigenetic Profiling and Screening Services
Accurate & Targeted Monoclonal Antibodies
Ion Channel Screening & Profiling Services

Hyperpolarization-Gated Channels

Cambridge Bioscience, through our collaboration with B’SYS, offers access to screening services for the following hyperpolarization-gated channel targets:

HCN1
Gene Name: HCN1
Description: Human HCN1 is a hyperpolarization-gated ion channel expressed mostly in the CNS, heart and retinal photoreceptors. HCN channels are thought to play a significant role in heart rate control, with HCN1 loss is linked to prolonged activation of photosensitive rods.

HCN4

Gene Name: HCN4
Description: The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN4 channels are the predominant HCN isoform in the sinoatrial node and contribute to pacemaker current that controls rhythmic activity in the heart and brain. The HCN4 therapeutic potential includes treatment of cardiac arrhythmia and ischemic heart disease.

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hyperpolarization-gated channel screening project with one of our specialists, please Click Here

Contact Our B'SYS Specialist, Vashu