hERG Concentration Response Assay
Cambridge Bioscience offers access to a hERG concentration response assay service from ChanTest enabling the determination of therapeutic safety margins and proarrhythmic potential.
hERG Concentration Response Assay
The hERG concentration-response assay (either GLP or non-GLP compliance) is a manual patch clamp assay that determines an IC50 value that in the context of intended therapeutic levels, provides an important benchmark for cardiac risk assessment. The assay can also be performed at physiological temperature.
Features of this Assay
• Quantitative assessment of inhibitory potency
• Physiological temperature standard
• Pre-testing concentration & solubility performed
• Concentration verification available
• Three week turnaround time with concentration analysis
Optional Assays Available
The following assays can be added to the standard project:
• Dose solution analysis – GLP & non-GLP
• Use-dependence analysis
• Temperature-dependence analysis
Additional Options Available
The following features can be added to the standard project:
• Additional copies of final report
• Copies of solution worksheets & data-collection forms
• Integrated risk assessment summary – dose-response, repolarization and in vivo data compiled in one report
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To discuss a hERG concentration response assay project, please contact our experienced team by Clicking Here
