Epigenetic Modulator Screening
Epigenetic modifications have been shown to regulate a wide range of physiological and pathological processes. Epigenetic alterations can also be used as the biomarkers and therapeutic targets in many diseases leading to led drug and biotechnology companies to actively search for intervention agents of epigenetic alterations.
Cambridge Bioscience offers access to a epigentic enzyme modulator screening service from Epigentek. This system provides a platform enabling the screening of modulators that target site-specific histone modifications, global DNA methylation and functional region-specific DNA methylation.
Features of the Epigentic Enzyme Modulator Screening Service
This service enables the following:
• Enhancement of drug discovery & development without the burden of increased staff & equipment
• Better drug candidates to be chosen for further development
• Determination of the specificity of lead candidates against a wide range of epigenetic targets
• Validation of lead candidates in a rapid, reliable & high throughput assay format
EpiModifier™ Epigenetic Modulator Screening System
Epigenetic modifications can be modulated by directly inhibiting modifying enzymes or blocking co-factor recruiting pathways. Development of these modulators would lead to the development of new therapeutic agents and improvement in disease treatment, especially cancer therapy.
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