Confirming Pluripotency

Mammalian development requires the derivation of over 200 unique cell types from a single totipotent cell progenitor. Embryonic stem (ES) cells are derived from the inner cell mass of the developing blastocyst and can be propagated in culture in an undifferentiated state while maintaining the capacity to generate any cell type in the body.

The transcription factors Oct4, Sox2, and Nanog have essential roles in early development and are required for the propagation of undifferentiated ES cells in culture.

Our Supply Partner System Biosciences has built lentivector-based transciptional Response Reporters that are responsive to Oct4 or Sox2 activity as response elements or Promoter Reporters for either Human or Mouse Oct4 and Nanog into the pGreenZeo, pRedZeo and pRedTK systems.

Cambridge Bioscience also offers pluripotency antibodies and iPS verification kits.

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