Cholecystokinin Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following cholecystokinin receptor targets:
CCKA
Synonym: CCK1
Validated Assay/Platform: Calcium
Description: Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. Two CCK receptors have been identified to mediate the effects of CCK/gastrin family: CCKA (or CCK-1) receptor and CCKB (or CCK-2 or gastrin receptor). The CCKA receptor has a more limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumours.
CCKB
Synonym: CCK2 & Gastrin receptor
Validated Assay/Platform: Calcium
Description: Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. Two CCK receptors have been identified to mediate the effects of CCK/gastrin family:CCKA (or CCK-1) receptor and CCKB (or CCK-2 or gastrin receptor). The CCKB receptor is the predominant subtype in the CNS where it is widely distributed, however, it also occurs in abundance in the gastro-intestinal tract. CCKB receptors have been found to be most abundant in the cerebral cortex, cerebellum, basal ganglia, and amygdale. Animal and human studies using CCKB receptor antagonists have suggested that anxiety, panic attacks, analgesia, and satiety may be modulated through the CCKB receptor.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
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