Cannabinoid Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following cannabinoid receptor targets:
CB1
Synonym: CNR1, CNR, CB-R, CB1A, CANN6 & CB1K5
Validated Assay/Platform: Binding & cAMP
Description: The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB2 cannabinoid receptor which is expressed primarily in the periphery, and GPR55 (Ryberg, 2007 ). When activated, the CB1 receptor inhibits adenylate cyclase through Gi. The CB1 receptor play a significant role in modulation of food intake (Cota, 2007)
CB1 (Rat)
Validated Assay/Platform: Binding & cAMP
Description: The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB2 cannabinoid receptor, which is expressed primarily in the periphery, and GPR55 (Ryberg, 2007). When activated, the CB1 receptor inhibits adenylate cyclase through Gi. The CB1 receptor plays a significant role in modulation of food intake (Cota, 2007).
CB2
Synonym: CNR2 & CX5
Validated Assay/Platform: Binding & cAMP
Description: The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids (Munro et al., 1993; Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB1 cannabinoid receptor, which is expressed primarily in brain, and GPR55 (Ryberg, 2007). When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi.
CB2 (Rat)
Synonym: CNR2 & CX5
Validated Assay/Platform: cAMP
Description: The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids (Munro et al., 1993; Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB1 cannabinoid receptor, which is expressed primarily in brain, and GPR55 (Ryberg, 2007). When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi.
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here
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