Adrenergic Receptors
Cambridge Bioscience, through our collaboration with ChanTest, offers access to GPCR screening and profiling services to the following adrenergic receptor targets:
Alpha1a
Synonym: ADRA1A
Validated Assay/Platform: Calcium
Description: Alpha-1 adrenergic receptors are widely distributed and mediate a variety of functions including smooth muscle contraction, cardiac stimulation, cellular proliferation, apoptosis and activation of hepatic gluconeogenesis and clycogenolysis. Three distinct alpha-1 adrenergic receptors have been identified and are known as alpha-1a, alpha-1b, and alpha-1c receptors.
Alpha2a
Synonym: ADRA2A
Validated Assay/Platform: Binding & cAMP
Description: Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2a adrenergic receptor is widely distributed in the CNS, lung, blood vessels and skeletal muscle and mediates vasoconstriction and inhibition of neurotransmission.
Alpha2b
Synonym: ADRA2B
Validated Assay/Platform: Binding & cAMP
Description: Three alpha2-adrenoceptors have been cloned, and are designated alpha2A, alpha2B and alpha2C. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2 adrenergic receptor is widely distributed in the CNS, lung, blood vessels and skeletal muscle and mediates vasoconstriction and modulation of neurotransmission.
Alpha2c
Synonym: ADRA2C
Validated Assay/Platform: Binding & cAMP
Description: Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2c adrenergic receptor is widely distributed in the CNS and in lung and mediates vasoconstriction and modulation of neurotransmission.
Beta1
Validated Assay/Platform: CNG
Beta2
Synonym: ADRB2
Validated Assay/Platform: cAMP
Description: β-Adrenoceptors (β1, β2, β3) are G protein-coupled receptors expressed in both central and peripheral sites and are activated either by norepinephrine released from symphathetic terminals or by epinephrine released from the adrenal medulla. Most β-adrenoceptor-mediated actions involve stimulation of intracellular adenylate cyclase and lead to relaxation of vascular, urogenital and bronchial smooth muscle, stimulation of cardiac rate and force, stimulation of rennin secretion, and stimulation of insulin and glucagons secretion. Besides its function in cardiac stimulation, β2 adrenoceptors play a major role in bronchodilation and are a good target for asthma and chronic obstructive pulmonary disease.
Beta3
Validated Assay/Platform: CNG
Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to both FLIPRTETRA® and FlexStation® 3 allowing you to select the right balance of speed, throughput and data quality to suit your needs.
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