Acid-Sensing Channels

Cambridge Bioscience, through our collaboration with ChanTest, offers access to screening services to the following acid sensing channel targets:

ASIC1a
Gene Name: ACCN2
Validated Assay/Platform: PatchXpress®
Description: The human ACCN2 gene encodes the pore-forming subunit of ASIC1a, a proton-activated, channel permeable to both Na+ and Ca2+ ions. ASIC1a channels widely expressed in the neurons of peripheral sensory and the central nervous system are therapeutic targets in pain and neurodegenerative diseases.

ASIC2a
Gene Name: ACCN1
Validated Assay/Platform: PatchXpress®
Description: The human ACCN1 gene encodes the pore-forming subunit of ASIC2a, a proton-activated, Na+-permeable channel. ASIC2a channels widely expressed in sensory neurons of the peripheral and central nervous systems are therapeutic targets in pain and neurodegenerative diseases.

ASIC3
Gene Name: ACCN3
Validated Assay/Platform: PatchXpress® & QPatch HT
Description: The human ACCN3 gene encodes the pore-forming subunit of ASIC3, a proton-activated, Na+-permeable channel. ASIC3 channels expressed primarily in dorsal root ganglion neurons are therapeutic targets in pain and inflammation.

Platforms Available
Cambridge Bioscience, through our collaboration with ChanTest, offers access to the widest range of screening platforms, from manual patch clamp up to the most recent innovations in automated electrophysiology, allowing you to select the right balance of speed, throughput and data quality to suit your needs.
To find out more about each of these platforms, please Click Here

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