Product Category: Ion Channel Cell Lines

ChanTest have launched a major initiative to build the World's most comprehensive collection of functionally validated ion channel cell lines which are now available to be licensed for use at your facility.

 

ChanTest are uniquely qualified to create this resource because of their unmatched experience of ion channel screening services and their recent investments in all of the major screening platforms used in drug discovery and safety testing today. Cell lines created in this project are being validated in-house by ChanTest using their Ionworks Quattro, PatchXpress, QPatch and FLIPRTETRA instruments.

 

Companies that license these cell lines will benefit from the most complete validation packages in the industry for these valuable, complex resources.

 

To learn more about ChanTest's new ion channel cell lines please complete this form and we will contact you with further details.

Calcium Channel Cell Lines
HCN Channel Cell Lines
P2X Receptor Cell Lines
Potassium Channel Cell Lines
Sodium Channel Cell Lines
TRP Channel Cell Lines
Other Ion Channel Cell Lines

Calcium Channels
A calcium channel is an ion channel which displays selective permeability to calcium ions (Ca2+). ChanTest has developed cell lines that express functional forms of the L-type, P/Q type, N-type and T-type calcium channels.

Cav1.1 (SKM L-type)
Cav1.2 (β4/α2δ Cardiac L-type)
Cav1.2 (β2 L-type)
Cav2.1 (β4/α2δ P/Q type)
Cav2.1 (β4 P/Q type)
Cav2.2 (β3/α2δ N-type)
Cav2.2 (β3/α2δ1 N-type)
Cav3.2 (T-type )

HCN Channel Cell Lines
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels are proteins that serve as ion channels across the plasma membrane of heart and brain cells. HCN channels are sometimes referred to as “pacemaker channels” because they help to generate rhythmic activity within groups of heart and brain cells. ChanTest has developed functional cell lines for each of the Human HCN channels

HCN1
HCN2
HCN3
HCN4

P2X Receptor Cell Lines
ChanTest has developed functional cell lines that express many of the P2X receptors.

P2X1
P2X2
P2X2/P2X3 
P2X3
P2X4
P2X7
 
Potassium Channel Cell Lines
ChanTest has created cell lines expressing each of the major types of potassium channel: calcium – activated, inward rectifying and voltage-gated potassium channels including the hERG channel.

BK (KCa1.1)
hERG (HEK293)
hERG (CHO)
IK (KCa3.1)
KCNQ1/KCNQ2
KCNQ2/KCNQ3
KCNQ2/KCNQ4
KCNQ3/KCNQ5
KCNQ4
Kir1.1
Kir2.1 (HEK293), (CHO)
Kir3.1/Kir3.2
Kir3.1/Kir3.4
Kir6.1/SUR2B
Kir6.2/SUR1  
Kir6.2/SUR2A
Kir6.2/SUR2B
Kv1.1
Kv1.2 (HEK93), (CHO)
Kv1.3 (HEK93), (CHO)
Kv1.4 (HEK93), (CHO)
Kv1.5 (HEK93), (CHO)
Kv2.1/Kv9.3
Kv3.4
Kv4.1
Kv4.2/KChiP2.2
Kv4.3 (HEK293), (CHO)
Kv4.3/KChiP2.2
Kv7.1 (KvLQT1-minK)
SK1 (KCa2.1) 
SK2 (KCa2.2)
SK3 (KCa2.3)

Sodium Channel Cell Lines
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. ChanTest has developed and validated cell lines that express a number of functional voltage-gated sodium channels.

Nav1.1
Nav1.2
Nav1.3
Nav1.4
Nav1.5
Nav1.6
Nav1.7
Nav1.8
Nav1.8/β3
NCX1
ENaC

TRP Channel Cell Lines
Transient receptor potential or TRP channels are a family of loosely related ion channels that are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are activated and regulated by a wide variety of stimuli and are expressed throughout the body.

To study this important class of ion channels, ChanTest has developed a wide range of cell lines that express these channels in a functional form.

TRPA1
TRPC1
TRPC4
TRPC6
TRPM2
TRPM4
TRPM5
TRPM7
TRPM8
TRPP1/TRPP2
TRPV1
TRPV4
TRPV6

Other Ion Channel Cell Lines
In addition to the ion channels listed above, ChanTest has also developed cell lines that express these other important channels in a functional form.

5-HT3A (serotonin receptor)    
ASIC-1a   
ASIC-2a
ASIC-3       
CFTR
CLC-1
CLC-2  
GABA-A receptor (α1β2γ2)
GABA-A receptor (α2β2γ2)
GABA-A receptor (α3β2γ2)    
GABA-A receptor (α5β2γ2)
ICRAC (native)
MDR1
Nicotinic receptor (nAChR) α1
Nicotinic receptor (nAChR) α3
Nicotinic receptor (nAChR) α3/β4
Nicotinic receptor (nAChR) α4/β2
Nicotinic receptor (nAChR) α7              
NMDA receptor (NR1/NR2A)   
NMDA receptor (NR1/NR2B)