Mannose Binding Lectin (MBL) is a C-type lectin that is an important element in innate immunity. MBL is a pattern recognition receptor, and upon recognition of the infectious agent, MBL triggers the activation of the lectin-complement pathway. Low MBL plasma concentrations have been associated with an inherited defect in opsonization.

Cambridge Bioscience offers a human MBL ELISA for the quantification of natural functional, mannan binding, human MBL in serum, plasma and culture medium. Unlike other MBL assays, any influence of the classical pathway has been eliminated by using a special MBL-binding buffer, which inhibits the binding of C1q to immunocomplexes and disrupts the C1 complex, while leaving the function of the MBL complex intact.

Features of this MBL ELISA
• Working time - 4 hours
• Concentration range - 0.41-100 ng/ml
• Limit of detection - 0.41 ng/ml
• Eliminates influence of the classical pathway

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