Genetically-Encoded Photoinducible Cell Cycle Inhibitor
ArrestRed (H2B-tKR) is a novel optogenetic tool, which can be used to study the roles of specific cell populations in development, regeneration, and carcinogenesis. The general expression of ArrestRed in mammalian cells does not interfere with cellular division. However, when illuminated by intense green light the expression of ArrestRed leads to the blockage of cell proliferation due to the generation of reactive oxygen species. This blockage lasts for about 24 hours before approximately 90% of ArrestRed expressing cells resume division.
Cambridge Bioscience offers a mammalian expression vector encoding the photoinducible cell cycle inhibitor ArrestRed from Evrogen. This vector can be transfected into mammalian cells by any known transfection method.
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