Plasminogen Activator Assays
Tissue plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are both serine proteases that function in the conversion of plasminogen to the active, broad-spectrum serine protease plasmin. Elevated activity of tPA can cause excessive haemorrhaging and reduced activity can lead to thrombosis and embolism. tPA can be used to treat thromboembolic events such as myocardial infarction and pulmonary embolisms within a certain window, minimising organ damage by dissolving clots. uPA is involved in initiating intracellular signal pathways that regulate cell proliferation, adhesion and migration and has been recently recognized as a prognostic marker for various cancers.
Cambridge Bioscience offers highly sensitive and easy to use FRET-based enzyme activity assays to investigate both the activity and the inhibition of tPA and uPA.
Benefits of using the SensoLyte® tPA and uPA Activity Assays
• Rapid 1 hour workflow
• Optimised for inhibitor screening
• Compatible with plasma, cell and tissue extracts
The SensoLyte® tPA and uPA Activity Assays are available in two formats:
1. SensoLyte® AFC uPA Activity Assay
Abs/Em 380 nm/500 nm
2. SensoLyte® AMC tPA Activity Assay
Abs/Em 354 nm/442 nm
Note: product availability depends on country. Product detail pages show availability of each product.